Endocrine Abstracts

Late effects of therapy can only become a meaningful concern, when the cure rate of the primary disorder is high enough to provide sufficient survivors. This happened for childhood cancer survivors around 50 years ago. The primary treatment modalities were surgery, radiotherapy, and combination chemotherapy. Amongst the most common treatment complications were dysfunction of the pituitary, thyroid, and gonad. The observation of gonadal damage and subsequent infertility led to ...

One of the success stories of modern medicine is the high cure rate of common childhood cancers. After an early period of denial, the existence of longterm complications, predominantly treatment-related, is acknowledged. By 2010 one in 250 of the adult population was a longterm survivor of childhood cancer. In 2014 420,000 childhood cancer survivors were estimated in the USA alone. Subsequently Moustoufi-Moab et al. (2016) reviewed 14,000 survivors of childhood cancer...

One of the success stories of modern medicine is the high cure rate of common childhood cancers. After an early period of denial, the existence of longterm complications, predominantly treatment-related, is acknowledged. By 2010 one in 250 of the adult population was a longterm survivor of childhood cancer. In 2014 420,000 childhood cancer survivors were estimated in the USA alone. Subsequently Moustoufi-Moab et al. (2016) reviewed 14,000 survivors of childhood cancer...

By 2010 one in 250 of the adult population was a long-term survivor of childhood cancer (CC). In 2014 there were an estimated 420,000 CC survivors in the USA alone(Robison et al. 2014). In a follow-up study of 14,000 aging survivors of CC (Mostoufi-Moab et al 2016), in whom the median age at cancer diagnosis was 6 years and at the last Follow-up 32 years, 44% had a least one endocrinopathy,16.7% had at least 2 endocrinopathies and 6.6% had 3 or more endocrino...

In adults severe GH deficiency has been a registered indication for the use of GH replacement since 1996. The UK prescribing policy has focused on a single biological endpoint, quality of life, whilst other European countries have adopted a holistic approach. How did this come about, why does the UK differ from its European neighbours, and is the UK practice satisfactory from an Endocrinologist's perspective ?Declaration of interest: There is no conflict...

Interpretation of biochemical results may be heavily influenced by fasting status (e.g. triglycerides), sample obtained under basal conditions or pharmacologically stimulated (e.g. growth hormone), time of day (e.g. testosterone level in pubertal boy), age and pubertal status (e.g. IGF-1 level), stage of menstrual cycle (e.g. progesterone level), menopausal status (e.g. gonadotrophin levels), pregnancy (e.g. thyroid function tests), stress associated with sample collection (e....

Context: We have previously demonstrated that, in cranially irradiated patients with normal peak GH responses to both the insulin tolerance test (ITT) and the growth hormone-releasing hormone plus arginine stimulation test (GHRH+AST), somatotroph reserve can be substantially reduced, while individual and overall spontaneous GH secretion remain entirely normal due presumably to a compensatory increase in hypothalamic stimulatory input within a partially damaged hypothalamic pit...

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested for the early diagnosis of myocardial infarction but clear definition of the physiological variability is necessary. Here, we studied the pulsatile and circadian variation in healthy individuals and compared copeptin to cortisol rhythms.Copeptin levels were sampled every 2...

Considerable dichotomy exists in the phenotype of adults with severe GHD of childhood (CO-GHD) and adult-onset (AO-GHD). Those with CO-GHD show immaturity. Adults with partial GHD (GH insufficiency (GHI), peak GH 3.1–7.0 μg/l) show a similar, but milder phenotype to adults with severe GHD. Whether a similar dichotomy relating to timing of onset is observed in CO-GHI and AO-GHI adults is not known.We studied 24 adults with GHI (CO-GHI n=1...

Aggressive angiomyxoma (AA) is a rare mesenchymal tumor which is more common in females, occurring predominantly in the pelvi-perineal region. It tends to be locally aggressive with high recurrence after primary excision. The majority of these tumors are positive for oestrogen and progesterone receptors. Hence hormonal manipulation provides the possibility of effective treatment.Since 2005, we have been treating two female patients with AA medically (see...